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HIV-1, resistance to

MedGen UID:
322868
•Concept ID:
C1836231
•
Finding
Synonym: HIV-1, RESISTANCE TO
 
OMIM®: 609423

Professional guidelines

PubMed

Preliminary report of transmitted drug resistance to integrase strand chain transfer inhibitors in treatment-naïve HIV infected patients.
Ferrer P, Ramos V, Puente MI, Afani A
Diagn Microbiol Infect Dis 2023 Dec;107(4):116083. Epub 2023 Sep 7 doi: 10.1016/j.diagmicrobio.2023.116083. PMID: 37778156
Drug Resistance to HIV-1 Integrase Inhibitors among Treatment-naive Patients in Jiangsu, China.
Yin YQ, Lu J, Zhou Y, Shi LE, Yuan F, Chen JS, Xuan Y, Hu HY, Zhang Z, Xu XQ, Fu GF, Wang B
Biomed Environ Sci 2021 May 20;34(5):400-403. doi: 10.3967/bes2021.053. PMID: 34059178
Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection.
Sluis-Cremer N, Wainberg MA, Schinazi RF
Future Microbiol 2015;10(11):1773-82. Epub 2015 Oct 30 doi: 10.2217/fmb.15.106. PMID: 26517190Free PMC Article

Recent clinical studies

Therapy

Capsid Inhibition with Lenacapavir in Multidrug-Resistant HIV-1 Infection.
Segal-Maurer S, DeJesus E, Stellbrink HJ, Castagna A, Richmond GJ, Sinclair GI, Siripassorn K, Ruane PJ, Berhe M, Wang H, Margot NA, Dvory-Sobol H, Hyland RH, Brainard DM, Rhee MS, Baeten JM, Molina JM; CAPELLA Study Investigators
N Engl J Med 2022 May 12;386(19):1793-1803. doi: 10.1056/NEJMoa2115542. PMID: 35544387
HIV-1 Integrase Inhibitors: A Comparative Review of Efficacy and Safety.
Scarsi KK, Havens JP, Podany AT, Avedissian SN, Fletcher CV
Drugs 2020 Nov;80(16):1649-1676. doi: 10.1007/s40265-020-01379-9. PMID: 32860583Free PMC Article
Long-Acting HIV Drugs for Treatment and Prevention.
Gulick RM, Flexner C
Annu Rev Med 2019 Jan 27;70:137-150. Epub 2018 Oct 24 doi: 10.1146/annurev-med-041217-013717. PMID: 30355266
Drug resistance in HIV-1.
Kuritzkes DR
Curr Opin Virol 2011 Dec;1(6):582-9. doi: 10.1016/j.coviro.2011.10.020. PMID: 22162985Free PMC Article
Maraviroc.
Fadel H, Temesgen Z
Drugs Today (Barc) 2007 Nov;43(11):749-58. doi: 10.1358/dot.2007.43.11.1131763. PMID: 18174962

Prognosis

Broadly neutralizing antibodies for HIV-1: efficacies, challenges and opportunities.
Liu Y, Cao W, Sun M, Li T
Emerg Microbes Infect 2020;9(1):194-206. Epub 2020 Jan 27 doi: 10.1080/22221751.2020.1713707. PMID: 31985356Free PMC Article
HIV Resistance Prediction to Reverse Transcriptase Inhibitors: Focus on Open Data.
Tarasova O, Poroikov V
Molecules 2018 Apr 19;23(4) doi: 10.3390/molecules23040956. PMID: 29671808Free PMC Article
HIV-1 reverse transcription.
Cimarelli A, Darlix JL
Methods Mol Biol 2014;1087:55-70. doi: 10.1007/978-1-62703-670-2_6. PMID: 24158814
HIV-1 superinfection.
Waters L, Smit E
Curr Opin Infect Dis 2012 Feb;25(1):42-50. doi: 10.1097/QCO.0b013e32834ef5af. PMID: 22156898
HIV-1 genotypic and phenotypic resistance.
Hanna GJ
Clin Lab Med 2002 Sep;22(3):637-49. doi: 10.1016/s0272-2712(02)00007-0. PMID: 12244590

Clinical prediction guides

Biomolecular condensates: insights into early and late steps of the HIV-1 replication cycle.
Di Nunzio F, Uversky VN, Mouland AJ
Retrovirology 2023 Apr 7;20(1):4. doi: 10.1186/s12977-023-00619-6. PMID: 37029379Free PMC Article
HIV-1 subtypes and drug resistance in children during antiretroviral therapy in Brazil.
de Andrade Arrais CR, Lima K, Barreiros M, Rodrigues JKF, Sousa NPS, Costa DD, Santos FDRP, Pereira GFM, E Silva Viana AI, Barros AK, Leal É
J Med Virol 2021 Aug;93(8):4908-4914. Epub 2021 Apr 8 doi: 10.1002/jmv.26988. PMID: 33788308
HIV Resistance Prediction to Reverse Transcriptase Inhibitors: Focus on Open Data.
Tarasova O, Poroikov V
Molecules 2018 Apr 19;23(4) doi: 10.3390/molecules23040956. PMID: 29671808Free PMC Article
HIV-1 antiretroviral resistance: scientific principles and clinical applications.
Tang MW, Shafer RW
Drugs 2012 Jun 18;72(9):e1-25. doi: 10.2165/11633630-000000000-00000. PMID: 22686620Free PMC Article
HIV-1 genotypic and phenotypic resistance.
Hanna GJ
Clin Lab Med 2002 Sep;22(3):637-49. doi: 10.1016/s0272-2712(02)00007-0. PMID: 12244590

Recent systematic reviews

HIV-1 resistance and virological failure to treatment with the integrase inhibitors bictegravir, cabotegravir, and dolutegravir: a systematic literature review.
Blanco-Arévalo JL, García-Deltoro M, Torralba M, Vélez-Díaz-Pallarés M, Castro A, Rubio-Rodríguez D, Rubio-Terrés C
AIDS Rev 2024;26(2):67-79. doi: 10.24875/AIDSRev.24000011. PMID: 39134019
HIV-1 Drug Resistance Detected by Next-Generation Sequencing among ART-Naïve Individuals: A Systematic Review and Meta-Analysis.
Ouyang F, Yuan D, Zhai W, Liu S, Zhou Y, Yang H
Viruses 2024 Feb 2;16(2) doi: 10.3390/v16020239. PMID: 38400015Free PMC Article
Public availability of HIV-1 drug resistance sequence and treatment data: a systematic review.
Rhee SY, Kassaye SG, Jordan MR, Kouamou V, Katzenstein D, Shafer RW
Lancet Microbe 2022 May;3(5):e392-e398. Epub 2022 Jan 19 doi: 10.1016/S2666-5247(21)00250-0. PMID: 35544100Free PMC Article
Drug resistance in the HIV-1-infected paediatric population worldwide: a systematic review.
Rojas Sánchez P, Holguín A
J Antimicrob Chemother 2014 Aug;69(8):2032-42. Epub 2014 Apr 30 doi: 10.1093/jac/dku104. PMID: 24788658
Systematic review of HIV drug resistance in Southeast Asia.
Trotter AB, Hong SY, Srikantiah P, Abeyewickreme I, Bertagnolio S, Jordan MR
AIDS Rev 2013 Jul-Sep;15(3):162-70. PMID: 24002200Free PMC Article

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